Optomyelitis associated with the presence of antibodies to myelin oligodendrocyte glycoprotein. Case report

Antibodies to myelin-oligodendrocyte glycoprotein (anti-MOG-IgG) is a specific biomarker that has been detected in peripheral blood from children with acute multiple encephalomyelitis (ADEM) as well adults aquaporin-4 (AQP4), associated seronegative opticoneuromyelitis spectrum disease (NMOSD), brainstem encephalitis, longitudinally disseminated transverse myelitis, and optic neuritis. Most experts now consider MOG-IgG-associated disorder (MOG-AD) an independent immunopathogenetically distinct classical sclerosis (MS) (AQP4)-IgG-positive optomyelitis. Isolated, bilateral, less frequently unilateral OH, simultaneous or sequential involvement of the eyes, most frequent clinical manifestation MOG-AD. Because significant overlap radiological picture, MOG-AD often misdiagnosed MS. Timely diagnosis critical ensure appropriate treatment. This article describes case anti-MOG-IgG late-onset ON initially diagnosed